Calibra Bioceuticals India Pvt. Ltd


Calibra, after extensive R & D, has ventured into the specialized segment of Acute cases of Inflammation and Pain. In Acute painful conditions, the patient requires immediate relief and Cure, without encountering any side effects. Perhaps for the first time, an effective and safe remedy for Acute inflammatory conditions is being offered.

Frozen shoulder medically referred to as adhesive capsulitis, is a disorder in which the shoulder capsule, the connective tissue surrounding the glen humeral joint of the shoulder, becomes inflamed and stiff, greatly restricting motion and causing chronic pain. Adhesive capsulitis is a painful and disabling condition that often causes great frustration for patients due to slow recovery. Movement of the shoulder is severely restricted. Pain is usually constant, worse at night, and when the weather is colder; and along with the restricted movement can make even small tasks impossible. Certain movements or bumps can cause sudden onset of tremendous pain and cramping that can last several minutes. This condition can last from five months to three years or more and is thought in some cases to be caused by injury or trauma to the area. It is believed that it may have an autoimmune component, with the body attacking healthy tissue in the capsule. There is also a lack of fluid in the joint, further restricting movement.

In addition to difficulty with everyday tasks, people who suffer from adhesive capsulitis usually experience problems sleeping for extended periods due to pain that is worse at night and restricted movement/positions. The condition also can lead to depression, pain, and problems in the neck and back.

Nuflex DS Capsule

Nuflex DS Capsule

Spondylosis is a term referring to degenerative osteoarthritis of the joints between the centra of the spinal vertebrae and/or neural foraminae. If this condition occurs in the zygapophysial joints, it can be considered facet syndrome. If severe, it may cause pressure on nerve roots with subsequent sensory and/or motor disturbances, such as pain, paresthesia, or muscle weaknessin the limbs. When the space between two adjacent vertebrae narrows, compression of a nerve root emerging from the spinal cord may result in sensory and motor disturbances, such as severe pain in the neck, shoulder, arm, back, and/or leg, accompanied by muscle weakness (radiculopathy ). Less commonly, direct pressure on the spinal cord (typically in the cervical spine) may result in myelopathy, characterized by global weakness, gait dysfunction, loss of balance, and loss of bowel and/or bladder control. The patient may experience a phenomenon of shocks (paresthesia) in hands and legs because of nerve compression and lack of blood flow. If vertebrae of the neck are involved it is labelled cervical spondylosis. Lower back spondylosis is labeled lumbar spondylosis.

Low back pain or lumbago is a common musculoskeletal disorder affecting 80% of people at some point in their lives. In the United States it is the most common cause of job-related disability, a leading contributor to missed work, and the second most common neurological ailment — only headache is more common. It can be either; acute, sub-acute or chronic in duration. With conservative measures, the symptoms of low back pain typically show significant improvement within a few weeks from onset. The majority of lower back pain stems from benign musculoskeletal problems, and are referred to as non specific low back pain; this type may be due to muscle or soft tissues sprain or strain, particularly in instances where pain arose suddenly during physical loading of the back, with the pain lateral to the spine. Over 99% of back pain instances fall within this category. The full differential diagnosis includes many other less common conditions.

Causes of lower back pain are varied. Most cases are believed to be due to a sprain or strain in the muscles and soft tissues of the back. Over activity of the muscles of the back can lead to an injured or torn ligament in the back which in turn leads to pain. An injury can also occur to one of the intervertebral discs (disc tear, disc herniation). Due to aging, discs begin to diminish and shrink in size, resulting in vertebrae and facet joints rubbing against one another. Ligament and joint functionality also diminishes as one ages, leading to spondylolisthesis, which causes the vertebrae to move much more than they should. Pain is also generated through lumbar spinal stenosis, sciatica and scoliosis.

Sciatica (sciatic neuritis) is a set of symptoms including pain that may be caused by general compression or irritation of one of five spinal nerve roots that give rise to each Sciatica nerve, or by compression or irritation of the left or right or both sciatic nerves. The pain is felt in the lower back, buttock, or various parts of the leg and foot. In addition to pain, which is sometimes severe, there may be numbness, muscular weakness, pins and needles or tingling and difficulty in moving or controlling the leg. Typically, the symptoms are only felt on one side of the body. Pain can be severe in prolonged exposure to cold weather.

A bone fracture is a medical condition in which there is a break in the continuity of the bone. A bone fracture can be the result of high force impact or stress, or trivial injury as a result of certain medical conditions that weaken the bones, such as osteoporosis, bone cancer, or osteogenesis imperfecta, where the fracture is then properly termed a pathologic fracture.

Shudh Guggul given in a dose of 1000 mg alleviates the acute inflammation and Pain.

Salai Guggul enhances the structural integrity of Joint cartilage. It helps to shrink the inflamed area by improving the blood supply to the affected area and enhances the repair to the damaged blood vessel. Studies have shown that the boswellic acids have an antiinflammatory action much like the conventional nonsteroidal antiinflammatory drugs (NSAIDs) used for inflammatory conditions. Boswellia inhibits pro-inflammatory mediators in the body, specifically leukotrienes via inhibition of 5-lipoxygenase, the key enzyme involved in the biosynthesis of pro-inflammatory leukotrienes. In contrast to NSAIDs, which are well known to disrupt glycosaminoglycan synthesis, thus accelerating articular damage in arthritic conditions, boswellic acids have been shown to significantly reduce glycosaminoglycan degradation. Consequently, long-term use of boswellia does not lead to irritation or ulceration of the stomach

Haridra acts by inhibiting Prostaglandin synthesis and a very effective anti-inflammatory agent.

Trikatu is a catalyst of other ingredients. Trikatu is an accepted Bioenhancer and hence the bioavailability of the formulation is enhanced.

Shunti has been used for ages in inflammatory conditions. Shunthi acts by inhibiting cyclo-oxyegenase (mediator of inflammation)

Acute Cases of Frozen Shoulder
Acute Cases of Spondylosis
Acute Cases of Lumbago
Acute Cases of Sciatica
Acute Cases of Fractures
Dosage of the Drug
2 capsules TID for 10 Days Followed by capsules BID for 10 Days in cases of acute inflammation & pain
Packing Details
10 x 10 Blister pack
Capsule Composition
Each capsule contains extracts equivalent to
Guggulu Commiphora Mukul 1000 mg.
Salai Guggul Boswellia Serrata 1000 mg.
Rasna Pluchea Lanceolata 600 mg.
Nirgundi Leaves 540 mg.
Haridra Curcuma Longa 200 mg.
Shunti Zingiber Officnale 200 mg.
Trikatu Zingiber officinale Piper 100 mg.